[Mesenteric lymph node cavitation in celiac disease: Report of four cases and literature review].

Service de maladies infectieuses et tropicales, NHC, CHU de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Electronic address: yvon.ruch@chru-strasbourg.fr. Service de gastro-entérologie, université de Tunis el Manar, hôpital universitaire La Rabta, Tunis, Tunisie. Service de maladies infectieuses et tropicales, NHC, CHU de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Service d'anatomie pathologique, hôpital de Hautepierre, CHU de Strasbourg, 1, avenue Molière, 67200 Strasbourg, France. Service de médecine interne et maladies métaboliques, médicale B, CHU de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Service d'immunologie clinique, NHC, CHU de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.

La Revue de medecine interne. 2019;(8):536-544
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Abstract

INTRODUCTION Mesenteric lymph node cavitation is an exceptional complication of celiac disease. We report four original observations of this syndrome, completed by a literature review. DISCUSSION The analysis of 38 cases showed that this complication occurred exclusively in adults, with a mean age at diagnosis of 54 years. It revealed the celiac disease in the majority of cases. Hyposplenism was almost systematically associated. The risk of lymphoma appeared higher, especially enteropathy-associated T-cell lymphoma. The prognosis was poor with nearly 50% mortality and seemed related to the clinical response to the gluten-free diet. CONCLUSION The severity of this complication deserves to be known and should lead to its research in celiac patients, especially in cases diagnosed in adulthood or in case of refractory disease.

Methodological quality

Publication Type : Case Reports ; Review

Metadata

MeSH terms : Celiac Disease